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I-Mab Explores TJM2 in Treating Severe COVID-19 Disease

Clinical study will explore the potential of TJM2, a mAb against Cytokine Release Syndrome, which is an overreaction of the immune system caused by inflammation

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By: Kristin Brooks

Managing Editor, Contract Pharma

I-Mab Biopharma is initiating the development of TJM2 (TJ003234) to treat cytokine storm in severe and critically ill patients with coronavirus disease (COVID-19). TJM2 is an I-Mab-discovered neutralizing antibody against human granulocyte-macrophage colony stimulating factor (GM-CSF), an important cytokine that plays a critical role in acute and chronic inflammation. The development will start following the U.S. FDA acceptance of I-Mab’s IND application, and will commence initially in the U....

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